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Scleroderma - Symptoms and causes - Mayo Clinic
Scleroderma Overview Scleroderma (sklair-oh-DUR-muh), also known as systemic sclerosis, is a group of rare diseases that involve the hardening and tightening of the skin. Scleroderma also may cause problems in the blood vessels, internal organs and digestive tract.

Scleroderma: What It Is, Risk Factors, Symptoms & Care
Scleroderma is a chronic condition, which means you’ll need to manage your symptoms for a long time (maybe the rest of your life). Visit a healthcare provider if you’re experiencing symptoms like pain and stiffness in your joints, especially if you notice any patches of thickened skin.

Scleroderma - Wikipedia
Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs. [2][6][8] The disease can be either localized to the skin or involve other organs as well. [2] Symptoms may include areas of thickened skin, stiffness, feeling tired, and poor blood flow to the fingers or toes with cold exposure. [1] One form of the condition ...

Scleroderma: Causes, Symptoms, and Treatment - WebMD
Scleroderma is a chronic autoimmune condition affecting the skin and internal organs. Learn about scleroderma symptoms, types, causes, and treatments.

Systemic Sclerosis (Scleroderma): Pictures, Symptoms, Causes
Systemic sclerosis (scleroderma) is an autoimmune disease that thickens connective tissue. It can tighten the skin and affect organs like the lungs and heart. Treatment can’t cure it but can ...

Scleroderma Symptoms, Types, Causes, & Risk Factors | NIAMS
Scleroderma causes areas of tight, hard skin, but can also harm your blood vessels and organs. Learn the causes and treatments of this skin disease.

Scleroderma - NHS
Scleroderma is the name for a range of conditions that affect your immune system (autoimmune conditions) and can cause hard, thickened areas of skin and sometimes problems with muscles, bones, internal organs and blood vessels.

What is Scleroderma? - National Scleroderma Foundation
Scleroderma is an autoimmune disease which means that it is a condition in which the body’s immune system attacks its own tissues.

Scleroderma Resource Center - National Scleroderma Foundation
Looking for a scleroderma resource? Find the resources you need to help you on your scleroderma journey. Fact sheets, helpful videos & more!

Systemic scleroderma - Wikipedia
Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. There are two major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse.

* Rheumatology101 LATEST NEWS *

*Filter: "Scleroderma"

Wireless sensor may help track scleroderma skin changes at home  Scleroderma News
Lifelong Journey: A Scleroderma Patient and Her Doctor  Cedars-Sinai
“My classmates and seniors gave me strange looks because of my appearance,': How this woman who is fighti  The Times of India
Scleroderma: Your Questions Answered  Yale Medicine
Scleroderma Awareness Month highlights rare condition  UT Physicians
For Scleroderma, Algorithm Helps Better Screen for Fatal Complication  Michigan Medicine
Scleroderma’s threat is more than skin deep  UCHealth
What Is Scleroderma? These Are the Signs You Could Have it  CreakyJoints
Tulane rheumatologist named Doctor of the Year by Scleroderma Foundation  Tulane University News
Systemic sclerosis physician video  Boehringer Ingelheim
A family battle with scleroderma  NIH MedlinePlus Magazine (.gov)
Can AI help doctors track lung disease in scleroderma patients?  European Lung Foundation
For lung cancer survivor, third time’s the charm  UT MD Anderson
Young woman battling Scleroderma grateful for specialized help at Temple Health  6abc Philadelphia
Signs of Scleroderma  Stanford Medicine

Common Rheumatological Symptoms

Joint Pain (Arthralgia) — Persistent discomfort or soreness in one or more joints caused by inflammation, wear and tear, or underlying autoimmune responses.
Morning Stiffness — Reduced joint mobility and tightness upon waking, often lasting over 30 to 60 minutes in inflammatory conditions like rheumatoid arthritis.
Joint Swelling and Edema — Visible enlargement of affected joints resulting from fluid accumulation in the synovial membrane and inflamed surrounding tissue.
Localized Warmth and Redness — Elevated temperature and erythema skin discoloration surrounding inflamed joints due to increased blood flow from localized inflammation.
Systemic Fatigue — Overwhelming exhaustion and lack of energy caused by ongoing chronic inflammatory cytokine activity throughout the body.
Raynaud's Phenomenon — Temporary color changes in fingers or toes turning white, blue, and red in response to cold or stress due to vascular spasms.
Malar or Butterfly Rash — Red or purplish facial rash spanning across the bridge of the nose and cheeks, classically associated with systemic lupus erythematosus.

Milestones in Rheumatology History

c. 400 BC: Hippocratic Corpus Coining — Hippocrates uses the term "rheuma" to describe body humors flowing into joints, establishing the early classical concept of joint inflammation.
1592: Formal Definition of Rheumatism — French physician Guillaume de Baillou introduces the modern term "rheumatism" to distinguish systemic acute arthritis from localized gout.
1800: Clinical Description of Rheumatoid Arthritis — Augustin Jacob Landré-Beauvais publishes the first detailed clinical description separating rheumatoid arthritis from gout, calling it "asthenic gout."
1859: Naming of Rheumatoid Arthritis — Sir Alfred Baring Garrod formally coins the term "rheumatoid arthritis" to clearly differentiate the inflammatory autoimmune condition from osteoarthritis and gout.
1940: Discovery of the Rheumatoid Factor — Erik Waaler discovers autoantibodies in the blood of patients with rheumatoid arthritis, laying the groundwork for serological autoimmune diagnostics.
1948: Introduction of Corticosteroid Therapy — Philip Hench and Edward Kendall demonstrate the dramatic anti-inflammatory effects of Compound E (cortisone) in treating rheumatoid arthritis, earning the Nobel Prize.
1998: Emergence of Biologic DMARDs — The FDA approves the first TNF-alpha inhibitors, ushering in the modern era of targeted biologic therapies for autoimmune rheumatic diseases.

Current Trends in Rheumatology Research

Chimeric Antigen Receptor (CAR) T-Cell Reset Therapy — Investigating engineered cellular therapies to achieve drug-free, durable clinical remissions by completely depleting pathogenic autoantibodies in severe refractory lupus and systemic sclerosis.
Selective TYK2 and Oral JAK Pathway Inhibition — Developing highly targeted, small-molecule oral inhibitors like deucravacitinib that disrupt specific cytokine signaling pathways while minimizing broader off-target side effects.
Targeted Pathogenic T-Cell and B-Cell Depletion — Evaluating novel biologics, such as rosnilimab and ianalumab, designed to selectively deplete overactive immune cell subpopulations involved in rheumatoid arthritis and Sjögren's disease.
Biomarker-Driven Precision Medicine — Utilizing pharmacogenomics and molecular biomarkers to predict individualized therapeutic responses and match systemic autoimmune conditions to specific biological mechanisms.
Subclinical Interception and Disease Prevention — Identifying seropositive individuals early using high-risk autoantibody profiles to initiate preventive targeted therapies before irreversible joint damage occurs.
Artificial Intelligence and Predictive Disease Modeling — Deploying machine learning algorithms across electronic health records and imaging modalities to forecast inflammatory flares and refine diagnostic accuracy.